Mary Catanese

Mary Catanese

Martinos Center, MGH • Radiology

Novel molecular insights into age-related alterations in white matter

Histone deacetylases are a class of enzymes that play a critical role in myelin formation in the brain. We demonstrated an age associated increase of specific histone deacetylase isoforms in particular in periventricular white matter, motivating further mechanistic investigation to improve our understanding of white matter alterations associated with cognitive decline across the lifespan, with further implications for demyelinating and neurodegenerative disease.

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